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PF-03049423 B
CAS No. 954138-07-9
PF-03049423 B( —— )
Catalog No. M37613 CAS No. 954138-07-9
PF-03049423 is a potent and highly selective phosphodiesterase-5A inhibitor with an IC50 of approximately 0.2 nM for rat and human thrombomodulin.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 120 | Get Quote |
|
| 5MG | 169 | Get Quote |
|
| 10MG | 259 | Get Quote |
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| 25MG | 413 | Get Quote |
|
| 50MG | 585 | Get Quote |
|
| 100MG | 767 | Get Quote |
|
| 200MG | 1035 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NamePF-03049423 B
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NoteResearch use only, not for human use.
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Brief DescriptionPF-03049423 is a potent and highly selective phosphodiesterase-5A inhibitor with an IC50 of approximately 0.2 nM for rat and human thrombomodulin.
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DescriptionPF-03049423 (Compound PF-5) free base is a potent and highly selective phosphodiesterase-5A inhibitor with an IC50 of about 0.2 nM for rat and human platelet enzyme. PF-03049423 free base can be used for the research of acute ischaemic stroke.
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In Vitro——
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In VivoPF-03049423 (Compound PF-5) (1-10 mg/kg; s.c.; b.i.d. for 7 days) promotes functional recovery in a rat model of severe stroke induced by permanent middle cerebral artery occlusion.PF-03049423 (1.0 mg/kg b.i.d. or 0.6 mg/kg q.d. for 7 days) improves poststroke sensory–motor behavioral outcome even when the treatment is initiated 24-72 hours after occlusion.Animal Model:Male Sprague-Dawley rats, middle cerebral artery occlusion (MCA-o) model Dosage:0.1, 1, or 10 mg/kg Administration:Subcutaneous injection, b.i.d. for 7 daysResult:Improved functional recovery at 1 mg/kg and 10 mg/kg.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number954138-07-9
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Formula Weight468.55
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Molecular FormulaC24H32N6O4
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Purity>98% (HPLC)
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Solubility——
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SMILESC(COCCC)N1C=2C(N=C(C1=O)N3CCN(CCO)CC3)=CN=C(C2)C=4C=CC(OC)=NC4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Menniti FS, et al. Phosphodiesterase 5A inhibitors improve functional recovery after stroke in rats: optimized dosing regimen with implications for mechanism. J Pharmacol Exp Ther. 2009 Dec;331(3):842-50.?
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